Research

The p53 family across cancer and physiology

Our programmes connect transcription and RNA control with metabolism, inflammation, comparative models and therapeutic development.

The p53 family network

We define the overlapping and isoform-specific functions of p53, p63 and p73 in tumor suppression, development and stress responses.

Central question

How do p53-family members cooperate, compete and compensate across tissues and cancers?

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A model to elucidate the interplay among mutant p53, NICD, p63, and p73.

RNA-binding proteins and feedback control

We study how RBM38 and related RNA regulators shape translation and feedback within the p53-family pathway.

Central question

How does post-transcriptional regulation fine-tune p53-family activity?

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A model for how the RBM38-eIF4E complex modulates p53-dependent tumor suppression.

FDXR, ferredoxins and metabolic homeostasis

We investigate how the FDXR–FDX1/2 electron-transfer system connects p53-family signaling to lipid metabolism, development and spontaneous tumor suppression.

Central question

How does a mitochondrial redox pathway influence lipid balance and cancer risk?

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Ninjurins and translational oncology

We study p53–NINJ1/2 feedback loops, inflammation and cell adhesion, then test pathway-derived peptides as potential therapeutic tools.

Central question

Can tumor-suppressive feedback loops be converted into tractable cancer therapies?

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