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Research programme 03
FDXR, ferredoxins and metabolic homeostasis
We investigate how the FDXR–FDX1/2 electron-transfer system connects p53-family signaling to lipid metabolism, development and spontaneous tumor suppression.
FDXR is a p53-family target and the sole mammalian ferredoxin reductase. The laboratory has developed a programme linking this pathway to iron-sulfur biology, lipid homeostasis, steatohepatitis, development and tumor susceptibility.
Mouse genetics, lipidomics and pathway analysis distinguish the essential and specialized roles of FDXR, FDX1 and FDX2 while revealing how the ABCA1–SREBP axis connects metabolism with tumor suppression.
01FDXR–FDX→
02Lipid homeostasis→
03Tissue physiology→
04Cancer risk