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Research programme 04
Ninjurins and translational oncology
We study p53–NINJ1/2 feedback loops, inflammation and cell adhesion, then test pathway-derived peptides as potential therapeutic tools.
NINJ1 and NINJ2 are cell-adhesion proteins with context-dependent roles in tissue injury, inflammation and tumorigenesis. The laboratory investigates their reciprocal regulation with p53 and how Ninjurin interactions influence cancer progression and metastasis.
A translational direction develops peptides derived from NINJ1 and NINJ2 that disrupt their interaction, induce p53 and suppress cancer-cell growth. Comparative oncology offers a route to evaluate concepts in naturally occurring canine disease.
01NINJ1/2→
02Pathway peptide→
03p53 activation→
04Growth control